Experts say term leads to vaccine misunderstanding

The idea of waning immunity has picked up steam in recent weeks, with some countries using it to justify rolling out third-dose COVID-19 vaccine boosters to their populations. But immunologists say the concept has been largely misunderstood.

While antibodies — proteins created after infection or vaccination that help prevent future invasions from the pathogen — do level off over time, experts say that’s supposed to happen. And it doesn’t mean we’re not protected against COVID-19.

Jennifer Gommerman, an immunologist with the University of Toronto, said the term “waning immunity” has given people a false understanding of how the immune system works.

“Waning has this connotation that something’s wrong and there isn’t,” she said. “It’s very normal for the immune system to mount a response where a ton of antibodies are made and lots of immune cells expand. And for the moment, that kind of takes over.

“But it has to contract, otherwise you wouldn’t have room for subsequent immune responses.”

Antibody levels ramp up in the “primary response” phase after vaccination or infection, “when your immune system is charged up and ready to attack,” said Steven Kerfoot, an associate professor of immunology at Western University.

They then decrease from that “emergency phase,” he added. But the memory of the pathogen and the body’s ability to respond to it remains.

Kerfoot said B-cells, which make the antibodies,

and T-cells, which limit the virus’s ability to cause serious damage, continue to work together to stave off severe disease long after a vaccine is administered. While T-cells can’t recognize the virus directly, they determine which cells are infected and kill them off quickly.

Recent studies have suggested the T-cell response is still robust several months following a COVID-19 vaccination.

“You might get a minor infection ... (but) all of those cells are still there, which is why we’re still seeing very stable effectiveness when it comes to preventing severe disease,” Kerfoot said.

A pre-print study released this week by Public Health England suggested protection against hospitalization and death remains much higher than protection against infection, even among older adults.

So the concept of waning immunity depends on whether you’re measuring protection against infection or against severe disease, Kerfoot said.

British Columbia, for example, saw 53 fully vaccinated COVID-19 patients hospitalized over the last two weeks, compared to 318 unvaccinated patients.

“You’ll hear people say that vaccines aren’t designed to protect infection, they’re designed to prevent severe disease,” Kerfoot said. “I wouldn’t say necessarily it’s the vaccine that’s designed to do one or another ... that’s just how the immune system works.”

Moderna released real-world data this week suggesting its vaccine was 96 per cent effective at preventing hospitalization, even amidst the more transmissible Delta variant, and 87 per cent effective at preventing infection — down from the 94 per cent efficacy seen in the clinical trials last year.

Pfizer-BioNTech has argued the same with its own data, and an advisory panel to the U.S.-based Food and Drug Administration voted Friday to endorse third doses for those aged 65 and older, or at high risk for severe disease. However, the panel rejected boosters for the general population.

Gommerman said the efficacy data presented by Moderna doesn’t signal the need for a third dose.

“The fact it protects 87 per cent against infection, that’s incredible,” she said.

Bancel said Moderna’s research, which has yet to be peer reviewed, suggested a booster dose could also extend the duration of the immune response by reupping neutralizing antibody levels.

But Dr. Sumon Chakrabarti, an infectious disease physician in Toronto, said looking solely at the antibody response is misleading, and could be falsely used as justification for an infinite number of boosters.

“This idea of waning immunity is being exploited and it’s really concerning to see,” Chakrabarti said. “There’s this idea that antibodies mean immunity, and that’s true ... but the background level of immunity, the durable T-cell stuff, hasn’t been stressed enough.”